Kaval Oğuz, E.2025-05-102025-05-1020212602-456X10.31594/commagene.10073892-s2.0-85152043016https://doi.org/10.31594/commagene.1007389https://hdl.handle.net/20.500.14720/5610Lake Van fish is one of few vertebrate species living in the lake, therefore it plays a very useful role as an indicator in determining lake pollution. Deltamethrin (DLT) is one of the pesticides used extensively in the Lake Van basin. In this study, it was aimed to determine the effects of DLT on the primary gill cell culture. Different concentrations of DLT (0.01, 0.1, 1, and 10 μM) were added to primary gill cell culture and the total antioxidant and oxidant levels, malondialdehyde (MDA), and 8- hydroxy-2'-deoxyguanosine (8-OHdG) levels were determined at the end of 24 and 48 h of administration. While the highest concentration of applied DLT (10 μM) caused a significant increase in the total oxidant level at 48 h, a decrease in the total antioxidant level was detected at 24 and 48 h (P < 0.05). The increase in MDA level, which is the product of lipid peroxidation of unsaturated fatty acids, with DLT concentrations of 1–10 μM at the end of 24 and 48 h was found to be significant (P < 0.05). As a result, it can be said that DLT caused oxidative stress in the primary gill cell culture of Lake Van fish exposed to concentrations of 1 and 10 μM, but no genotoxic effect was observed. © 2021, ABADER (Adıyaman Bilimsel Arastırmalar Dernegi). All rights reserved.eninfo:eu-repo/semantics/openAccessDna DamageLake VanLipid PeroxidationOxidative StressPesticideArticle