Yildiz, HanifiAlp, Hamit HakanSunnetcioglu, AyselEkin, SelamiCilingir, Buket Mermit2025-05-102025-05-1020210147-95631527-328810.1016/j.hrtlng.2020.04.0172-s2.0-85085576524https://doi.org/10.1016/j.hrtlng.2020.04.017https://hdl.handle.net/20.500.14720/6962Ekin, Selami/0000-0001-5922-0348; Yildiz, Hanifi/0000-0003-0735-5034; Alp, Hamit Hakan/0000-0002-9202-4944Introduction: As asthma has a wide range of inflammatory pathways, the researchers were focused on the markers that may be associated with exacerbation and stability in asthma. Objective: Our aim is to investigate the serum levels of some inflammatory markers and cytokines in stable and exacerbated asthmatic patients. Methods: The study included in 59 non-smoker asthma patient (Exacerbated=25, Stable=34) and 30 healthy volunteers. The serum level of periostin, YKL-40, IL-4, IL-5, IL-37, and TNF-alpha were detected by enzyme-linked immunosorbent assay. Results: Except for IL-37, the periostin, YKL-40, IL-4, IL-5, and TNF-alpha level in asthmatic patients were significantly higher than those of healthy control. In the exacerbated group, the periostin, YKL-40, IL-5, and TNF-alpha level were significantly higher than stable asthma and healthy control groups. The serum levels of IL-4 in exacerbated and stable asthma groups were significantly higher than healthy control group. There was a significant difference between IL4 levels, in stable asthma and healthy control groups. In exacerbated asthma group, IL-37 level was significantly lower than stable and healthy control groups. The highest area under the ROC curve (AUC) was found for IL-4. While there was a significant negative correlation between these parameters and FEV1, there was a positive correlation between IL-37 and FEV1, but not significant. Conclusions: This study showed that increased serum periostin, YKL-40, IL-5, IL-4, and TNF-alpha and decreased serum IL-37 were associated with exacerbation showing uncontrolled asthma. (C) 2020 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessAsthmaExacerbationPeriostinYkl-40Il-37CytokinesArticle501Q1Q217718332475627WOS:000600693100031