Ermaya, MasallahDemir, HalitDemir, CananKanmaz, Huseyin2025-05-102025-05-1020212459-145910.33808/clinexphealthsci.861254https://doi.org/10.33808/clinexphealthsci.861254https://hdl.handle.net/20.500.14720/8395Demir, Canan/0000-0002-4204-9756; Demir, Halit Batuhan/0000-0002-2746-7941Objective: The purpose of this study is to determine the relationship between enzymatic antioxidants such as glutathione reductase and glutathione s-transferase and prolidase and adenosine deaminase in patients diagnosed with pancreatic cancer. Methods: Prolidase, adenosine deaminase, glutathione s-transferase and glutathione reductase activities were determined spectrophotometrically in blood sera collected from patients and healthy control subjects included in the study. Results: In patients with pancreatic cancer, the mean value of glutathione reductase and glutathione s-transferase enzymes decreased, while the mean value of prolidase, and adenosine deaminase, enzyme activities increased (p <0.05). Conclusion: In this study, in which prolidase, enzyme activity was first measured in pancreatic cancer, high prolidase, activity can be evaluated as a factor that increases the risk of cancer. Prolidase, adenosine deaminase, glutathione reductase and glutathione s-transferase enzyme activities may play an important role in the etiopathogenesis of pancreatic cancer.eninfo:eu-repo/semantics/openAccessAdenosine DeaminaseCancerGlutathione ReductaseGlutathione S-TransferasePancreatic CancerArticle