Gunes, YilmazCeylan, YemlihanTuncer, Mustafa2025-05-102025-05-1020101016-51692-s2.0-79960004385https://hdl.handle.net/20.500.14720/16975Gunes, Yilmaz/0000-0003-3817-851XThere is no consensus on the management of intracardiac mural thrombi. A 59-year-old man underwent echocardiographic examination for right leg pain and pulse deficits in the right lower extremity, which showed severe left ventricular systolic dysfunction and a bellshaped protruding mobile thrombus in the left ventricular apex. Due to high risk of surgery, 50 mg recombinant tissue-type plasminogen activator (rt-PA) was slowly infused over eight hours. Serial echocardiographic examinations showed a progressive decrease in the size of the thrombus within the first hours of rt-PA infusion, resulting in complete lysis after 24 hours. Lowdose and slow-infusion thrombolytic therapy may be an alternative therapy for left ventricular thrombi when surgery is not feasible.trinfo:eu-repo/semantics/closedAccessEchocardiographyThrombolytic Therapy/MethodsThrombosis/Drug TherapyTissue Plasminogen Activator/Therapeutic UseArticle387N/AQ348949121206203WOS:000421514300007