Tuluce, YasinGorgisen, GokhanGulacar, Ismail MusabKoyuncu, IsmailDurgun, MustafaAkocak, SuleymanKaya, Zehra2025-05-102025-05-1020180250-70051791-753010.21873/anticanres.128322-s2.0-85052994289https://doi.org/10.21873/anticanres.12832https://hdl.handle.net/20.500.14720/5935Kaya, Zehra/0000-0001-6222-7882; Koyuncu, Ismail/0000-0002-9469-4757; Durgun, Mustafa/0000-0003-3012-7582; Akocak, Suleyman/0000-0003-4506-5265; Tuluce, Yasin/0000-0002-7312-5934Background/Aim: Chemotherapeutic treatment options are often ineffective due to the development of resistance in cancer cells. Therefore, developing new anti-cancer agents is crucial for cancer treatment. Some triazine derivatives, their complexes and Copper(II) have anti-cancer effects on cancer cells. In this study, we aimed to determine the anti-proliferative effect of the novel synthesized Cu(II) complex with 3-(3-(4-fluorophenyl)triaz-1 -en- 1-yl) benzene-sulfonamide compound on the common cancer cell lines HeLa, MDA-MB-231, A2780 and MCF7. Materials and Methods: Common cancers cell lines were treated with copper complexes. Cell viability and apoptotic gene expression were examined. Results: Novel synthesized copper complex led to decreased viability of all cell lines. It also induced apoptosis via increasing the expression of caspase-3, caspase-9, Bax and p53 proteins and decreasing ERK expression. Conclusion: The novel synthesized copper complex has a significant inhibitory effect on the viability of cancer cell lines and can be considered as an antitumor agent for further studies.eninfo:eu-repo/semantics/openAccessMetal ComplexesAnticancer CompoundsCopper ComplexesApoptosisArticle389Q4Q35115512030194157WOS:000449957600018