Celik, IOguz, HDemet, ÖDönmez, HHBoydak, MSur, E2025-05-102025-05-1020000007-16681466-179910.1080/7136549542-s2.0-0034267283https://doi.org/10.1080/713654954https://hdl.handle.net/20.500.14720/15203Oguz, Prof. Dr. Halis/0000-0002-9236-0630; Sur, Emrah/0000-0002-3513-7424; Donmez, Hasan Huseyin/0000-0003-4664-8489; Boydak, Murat/0000-0002-3251-11771. Protective action of an enzyme-linked polyvinylpolypyrrolidone (PVPP, Mycofix(R) Plus) against the immunosuppressive effect of afatoxins (AF) was evaluated by determination of peripheral blood TP-lymphocyte proportions and splenic plasma cell counts. Histological changes in lymphoid organs were also investigated by light microscopy. One-d-old broiler chicks (Hybro) received 2.5 mg/kg diet AF (83.06% AFB(1), 12.98% AFB(2), 2.84% AFG(1), 1.12% AFG(2)) with or without PVPP (3 g/kg diet) until 21 d of age. 2. When compared with the controls, AF treatment significantly decreased peripheral T-lymphocyte counts. AF caused a slight decrease in splenic plasma cell counts. The addition of PVPP to an AF-containing diet significantly increased T-lymphocyte counts. Splenic plasma cell counts were numerically intermediate between control and AF groups. 3. The dietary addition of PVPP to AF-free diet did not significantly alter either T-lymphocyte or splenic plasma cell counts.eninfo:eu-repo/semantics/closedAccessArticle414Q2Q243043911215492WOS:000165512500007