Baskiran, YusufUckan, KazimKaracor, TalipCelegen, IzzetAcar, Zuat2025-05-102025-05-1020232149-93222149-933010.4274/tjod.galenos.2023.715092-s2.0-85171379588https://doi.org/10.4274/tjod.galenos.2023.71509https://hdl.handle.net/20.500.14720/9708Acar, Zuat/0000-0002-3485-1554; Karacor, Talip/0000-0003-1349-1569; Baskiran, Yusuf/0000-0003-1123-6062; Celegen, Izzet/0000-0002-2749-953XObjective: This study aims to investigate the impact of maternal albumin and serum electrolyte levels on the efficacy of single-dose methotrexate (SD-Mtx) therapy for ectopic pregnancies. Building on previous research, recommendations are provided to enhance the success of SD-Mtx therapy in the management of ectopic pregnancy. Materials and Methods: Conducted at a tertiary center gynecology clinic, the study included 353 patients diagnosed with ectopic pregnancy and treated with SD-Mtx from 2012 to 2023. Patients who responded positively to SD-Mtx treatment comprised Group 1 (n=313), while those requiring surgical intervention due to failed SD-Mtx therapy constituted Group 2 (n=40). Through the hospital's digital database, patient data including complete blood count, biochemistry, and hormone test results were retrospectively examined. Results: The mean beta-hCG value was 1996 IU/mL for Group 1 in contrast to 2058 IU/mL for Group 2. There was no statistically significant difference in beta-hCG levels between the two groups. Notably, Group 1 patients exhibited lower serum magnesium levels but higher potassium levels compared to Group 2 patients, with statistically significant differences. Furthermore, Group 1 patients had higher albumin levels than those in Group 2, with a statistically significant difference. Conclusion: Successful SD-Mtx treatment was associated with lower maternal serum magnesium levels and higher potassium and albumin levels. Considering electrolyte levels before administering SD-Mtx and addressing any imbalances could potentially enhance treatment success. Additionally, restoring low albumin levels might improve the efficacy of SD-Mtx treatment for ectopic pregnancies. While this study suggests these trends, further extensive studies with a larger sample size are necessary to establish more definitive evidence.eninfo:eu-repo/semantics/openAccessEctopic PregnancyMethotrexateInflammationBeta-HcgSerum ElectrolytesAlbuminArticle203N/AQ321421837667559WOS:001073610900010