Mansour, MarahRaya, MariaJrdy, Abd AlrahmanSires, Abdoul MajidWardeh, Jad AlhaqAlsbekhan, Almoataz BallahAlrebdawi, Khaled2025-05-102025-05-1020232042-881210.1093/jscr/rjad6522-s2.0-85183308014https://doi.org/10.1093/jscr/rjad652https://hdl.handle.net/20.500.14720/9576Raya, Maria/0000-0003-1402-3935; Sires, Abdoul Majid/0000-0003-4229-1830; Safadi, Mhd Firas/0000-0002-7386-1640Partial androgen insensitivity syndrome is a rare X-linked disorder. While most cases are sporadic, familial cases are less frequent. The management of this syndrome follows a multidisciplinary approach involving hormone substitution, psychological counseling, and surgical procedures. We present a case series of three young siblings with familial partial androgen insensitivity syndrome who presented with a female phenotype. All of them were managed with hormonal treatment for 6 months followed by surgical reconstruction. The operative procedure involved phalloplasty and urethroplasty using amniotic membrane transplant, which is considered a novel technique in this group of patients. No intraoperative or postoperative complications were observed and good results were achieved within 2 years of follow-up.eninfo:eu-repo/semantics/openAccessAndrogen Insensitivity SyndromeAndrogen Receptor Insensitivity SyndromeSexual DevelopmentGender TransitionAmniotic Membrane AllograftArticle202312N/AQ338076312WOS:001114970400009