Akinay, YukselTopuz, MehmetOter, CigdemKaratas, Erkan2026-04-022026-04-0220262468-023010.1016/j.surfin.2026.1089212-s2.0-105032262903https://hdl.handle.net/123456789/30253https://doi.org/10.1016/j.surfin.2026.108921Rapid corrosion and susceptibility to infection limit the clinical use of magnesium (Mg) alloys as biodegradable implant materials. This study reports the development of a novel Alginate-CuO-MXene (Ti3C2Tx) hybrid coating on AZ31 Mg alloy to overcome these challenges. The Alginate-CuO-MXene hybrid films were prepared through a solution-casting technique. Comprehensive chemical, morphological, and structural analyses were conducted to confirm the incorporation of CuO nanoparticles and MXene phases within the alginate matrix, as well as their impact on the corrosion behavior. In electrochemical tests, the Alginate-CuO-MXene coating exhibited the highest performance, decreasing the corrosion current density (Icorr) from 27.6 to 6.34 mu A & sdot;cm- 2, corresponding to a 77 % reduction relative to uncoated AZ31. Nyquist and Bode diagrams also confirmed that the hybrid coating formed a homogeneous and high-resistance barrier limiting ion diffusion. In addition to corrosion protection, agar diffusion and propidium iodide (PI) staining tests revealed that the Alginate-CuO-MXene coating provides broad-spectrum antibacterial activity. Moreover, the coating supported high osteoblastic viability and favorable cell adhesion, indicating a biologically safe antibacterial interface. In conclusion, the developed Alginate-CuO-MXene coating both slows the rapid biodegradation of Mg alloys and confers strong antibacterial properties while maintaining cytocompatibility, highlighting its potential as a clinically relevant surface modification strategy for Mg-based biodegradable implants.eninfo:eu-repo/semantics/closedAccessAlginateCoatingCuoTi3C2Tx MXeneAZ31 Mg AlloyArticle