Talmac, Ayse Gul OnerKoc, AlaettinKavut, Busra Sumeyye2025-05-102025-05-1020250340-36961432-069X10.1007/s00403-024-03708-42-s2.0-85216717893https://doi.org/10.1007/s00403-024-03708-4https://hdl.handle.net/20.500.14720/11165The purpose of this study was to determine the levels of IL-17, Bcl-3 and I kappa B zeta gene expression in the gingival crevicular fluid (GCF) of psoriatic and healthy individuals and to compare the clinical periodontal parameters in the patient and control groups. A total of 10 psoriasis patients and 2 healthy patients in the control group were included in the analysis for IL-17, Bcl-3, and I kappa B zeta gene expression in the GCF. Periodontal health, gingival index, plaque index, and mobility (using a periotest device) levels were compared between the groups. While considering the down-expressed patients, the expression level of the Bcl-3 gene showed the most variability among the genes studied in psoriasis disease. IL-17 gene expression levels were significantly higher and up-regulated in all patients compared to the control group. In addition, when comparing IL-17 with Bcl-3, IL-17 gene expression was notably high in all patients except patients 4, 9 and 10. The highest expression levels of the I kappa B zeta gene were observed in the patient sample, except for patients 7 and 8. While plaque index, gingival index, and pocket depth parameters were higher in the psoriasis group, there was no significant difference between the two groups (p = 0.257, p = 0.390, p = 0.240, respectively). In the periotest (mobility) parameter, while the mean value was higher in the psoriasis group significantly (p = 0.030), clinically mean values of two groups were in the same grade according to Miller mobility index. The I kappa B zeta gene showed notable high expression levels in psoriasis patients. It was concluded that psoriasis may be associated with periodontitis.eninfo:eu-repo/semantics/closedAccessPsoriasisGene ExpressionPeriodontal HealthPeriodontitisDetermination of Il-17, Bcl-3 and Iκbζ Expression Levels in the Gingival Crevicular Fluid of Psoriasis PatientsArticle3171Q2Q239786665WOS:001394980600003