Vatansever, Erol CanKilic, KubraOzer, Merve SinemKoza, GaniMenges, NurettinBalci, Metin2025-05-102025-05-1020150040-40391873-358110.1016/j.tetlet.2015.07.0902-s2.0-84940721375https://doi.org/10.1016/j.tetlet.2015.07.090https://hdl.handle.net/20.500.14720/7697Menges, Nurettin/0000-0002-5990-6275A concise and regioselective approach for the synthesis of 2,3-disubstituted thiophene derivatives has been developed. The synthetic strategy relies on the reaction of an in situ generated 2-mercaptoacetaldehyde with various alkynones. Furthermore, we calculated the energy gap between the HOMO and the LUMO orbitals of all compounds and observed that the introduction of a strong electron-withdrawing group decreased the HOMO-LUMO energy gap. (C) 2015 Elsevier Ltd. All rights reserved.eninfo:eu-repo/semantics/closedAccessAlkynesCyclizationAlkynones2-Mercaptoacetaldehyde2,3-Disubstituted ThiophenesArticle5640Q3Q353865389WOS:000362533900004