Kuzu, BurakGenc, HasanTaspinar, MehmetTan, MeltemMenges, Nurettin2025-05-102025-05-1020181042-71631098-107110.1002/hc.214122-s2.0-85045399210https://doi.org/10.1002/hc.21412https://hdl.handle.net/20.500.14720/7582Menges, Nurettin/0000-0002-5990-6275; Kuzu, Burak/0000-0002-7305-7177Imidazo-1,5-alkynyl alcohol derivatives were synthesized, and they were cyclized to imidazo-1,4-oxazines by means of cesium carbonate. Propargyl-allene isomerization was examined, and the reaction mechanism was proposed. Moreover, cytotoxicity of synthesized molecules against LN405 cell lines was investigated by means of structure-activity relationship (SAR). With SAR study, toxicities of some functional groups have been shown. In addition, two lead compounds were tested against DNA damaging.eninfo:eu-repo/semantics/closedAccessArticle291Q4Q4WOS:000429711100003