Korkmaz, VakkasKurdoglu, ZehraAlisik, MuratCetin, OrkunKorkmaz, HilalSurer, HaticeErel, Ozcan2025-05-102025-05-1020161476-70581476-495410.3109/14767058.2016.11495612-s2.0-84961197812https://doi.org/10.3109/14767058.2016.1149561https://hdl.handle.net/20.500.14720/14907Alisik, Murat/0000-0003-0434-3206; Kurdoglu, Zehra/0000-0001-5191-1072Aim: To investigate the effects of severity of preeclampsia on thiol-disulfide homeostasis (TDH).Material and methods: A total of 108 participants were divided into three groups: Group 1 was composed of pregnant women with no obstetric complications, Group 2 included pregnant women with mild preeclampsia, and Group 3 consisted of pregnant women with severe preeclampsia. TDH parameters were determined, and comparisons of clinical and routine laboratory test findings were made in all groups.Results: The serum native thiol level was 347.927.4 in the control group, 237.2 +/- 44.2 in the mild preeclampsia group, and 227.9 +/- 53.1 in the severe preeclampsia group (p<0.001). The serum total thiol level was 376.1 +/- 31.9 in the control group, 261.8 +/- 49.4 in the mild preeclampsia group, and 248.3 +/- 57.4 in the severe preeclampsia group (p<0.001). The disulfide level was 14.1 +/- 5.6 in the control group, 12.3 +/- 5.1 in the mild preeclampsia group, and 10.2 +/- 4.8 in the severe preeclampsia group (p=0.001). A significant correlation between impairment in degree of TDH and severity of preeclampsia was observed.Conclusion: TDH was impaired in women with preeclampsia, and this impairment increased with disease severity. Therefore, impaired TDH may have a role in the etiopathogenesis of the disease.eninfo:eu-repo/semantics/closedAccessDisulfidePreeclampsiaThiolArticle2923Q4Q23848385326828694WOS:000384540600019