Kara, HAydin, SAgargun, MYOdabas, OYilmaz, Y2025-05-102025-05-1019960022-534710.1016/S0022-5347(01)65467-32-s2.0-0029949554https://doi.org/10.1016/S0022-5347(01)65467-3https://hdl.handle.net/20.500.14720/8124Purpose: The efficacy of the selective serotonin re-uptake inhibitor fluoxetine in the treatment of premature ejaculation was examined. Materials and Methods: The study comprised 17 patients with premature ejaculation who presented to the urology clinic of our medical school. In this double-blind study the patients were randomized into treatment groups receiving 20 mg. fluoxetine daily for 1 week and 40 mg. daily afterward (group 1) or 1 capsule placebo daily for 1 week and 2 capsules daily afterward (group 2). The groups were evaluated according to the latent period of intravaginal ejaculation. Results: The latent period of intravaginal ejaculation in group 1 was significantly longer than that in group 2. Nausea, headache and insomnia were reported side effects. Conclusions: Fluoxetine may be regarded as a safe and effective alternative in the treatment of premature ejaculation.eninfo:eu-repo/semantics/closedAccessFluoxetine, Ejaculation, Psychosexual DysfunctionsArticle1565Q1Q1163116328863556WOS:A1996VM11700023