Uslu, BÖzkan, SASentürk, Z2025-05-102025-05-1020060003-26701873-432410.1016/j.aca.2005.09.0342-s2.0-29244482748https://doi.org/10.1016/j.aca.2005.09.034https://hdl.handle.net/20.500.14720/12250Ozkan, Sibel/0000-0001-7494-3077; Uslu, Bengi/0000-0002-7327-4913; Senturk, Zuhre/0000-0002-0356-9345The electrochemical properties of valacyclovir, an antiviral drug, were investigated in pH range 1.8-12.0 by cyclic, differential pulse and square-wave voltammetry. The drug was irreversibly oxidized at a glassy carbon electrode in one or two oxidation steps, which are pH-dependent. For analytical purposes, a very resolved diffusion controlled voltammetric peak was obtained in Britton-Robinson buffer at pH 10.0 using differential pulse and square-wave modes. Limits of detection were 1.04 x 10(-7) and 4.60 x 10(-8) M for differential pulse and square-wave voltammetry, respectively. The applicability to direct assays of tablets, spiked human serum and simulated gastric fluid, was described. (c) 2005 Elsevier B.V. All rights reserved.eninfo:eu-repo/semantics/closedAccessValacyclovirCyclic VoltammetryDifferential Pulse VoltammetrySquare-Wave VoltammetryGlassy Carbon ElectrodeTabletBiological FluidsConference Object