Gumus, AysegulMert, Kudret2025-05-102025-05-1020150793-02832191-019710.1515/hc-2014-01552-s2.0-84922495853https://doi.org/10.1515/hc-2014-0155https://hdl.handle.net/20.500.14720/15966Gumus, Aysegul/0000-0002-1613-7074The stereoselective synthesis of a 1,2,3-triazolod-lactone (+)-6 derived from a homoallyl alcohol (S)-(-)-1 backbone was accomplished. 2-Thienyl-substituted allyl alcohol rac-1 was efficiently resolved through enzymatic method with high ee (95%) and known stereochemistry. An enantiomerically enriched azidoalcohol (+)-4 derived from a homoallyl alcohol was subjected to the Huisgen 1,3-dipolar cycloaddition reaction with diethyl acetylenedicarboxylate, followed by intramolecular cyclization of the corresponding cycloadduct (+)-5, to yield the 1,2,3-triazolo-delta-lactone derivative.eninfo:eu-repo/semantics/openAccessAzide-Alkyne CycloadditionEnzymatic Resolution2-Azidoalcohol1,2,3-Triazolo-Delta-LactoneArticle211Q2Q34346WOS:000349471400008