Hama, A. K.Algso, M. A. S.Kavak, E.Kivrak, A.2025-05-102025-05-1020201070-42801608-339310.1134/S10704280200702222-s2.0-85090767500https://doi.org/10.1134/S1070428020070222https://hdl.handle.net/20.500.14720/7079Kavak, Emrah/0000-0002-6161-2030; Kivrak, Arif/0000-0003-4770-2686The Sonogashira cross coupling reaction of 2-bromo-5-(4-methoxyphenyl)thiophene and 1-ethynyl-2-(methylsulfanyl)benzene gave 2-(4-methoxyphenyl)-5-{[2-(methylsulfanyl)phenyl]ethynyl}thiophene which was subjected to electrophilic cyclization by the action of iodine to obtain 3-iodo-2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene. Stille and Sonogashira coupling reactions of the latter afforded a series of new 3-substituted 2-[5-(4-methoxyphenyl)thiophen-2-yl]-1-benzothiophene derivatives of potential pharmacological interest.eninfo:eu-repo/semantics/closedAccessBenzothiophenesHeteroaromatic CompoundsCyclization ReactionsCoupling ReactionsArticle567Q4Q412721278WOS:000567893800022