Caliskan, NeclaSogut, EdaSaka, CaferYardim, YavuzSenturk, Zuhre2025-05-102025-05-1020101386-207310.2174/1386207107919203562-s2.0-77955733616https://doi.org/10.2174/138620710791920356https://hdl.handle.net/20.500.14720/1681Senturk, Zuhre/0000-0002-0356-9345; Yardim, Yavuz/0000-0002-9587-096X; Gokirmak Sogut, Eda/0000-0002-7707-3924; Saka, Cafer/0000-0003-2534-5921This paper is the first report describing the characterization of local diatomite of Caldiran-Van region (Eastern Anatolia, Turkey). Special attention was paid to the ability of its electroanalytical performance at modified electrodes and to the potential application of diatomite-modified electrode. For this purpose, the determination of Naratriptan which is a novel oral triptan (5-hydroxytryptamine receptor agonist) in migraine treatment, by means of a carbon paste electrode modified with 10% (w/w) of diatomite was studied using cyclic and square-wave voltammetry. The experimental conditions that affect the electrode reaction process were studied in terms of pH of the supporting electrolyte, scan rate, accumulation variables, modifier composition and square-wave parameters. Using square-wave stripping mode, the drug yielded a well-defined voltammetric response in Britton-Robinson buffer, pH 4.0 at 0.84 V (vs Ag/AgCl) (a pre-concentration step being carried out with an open circuit at 120 s). The process could be used to determine Naratriptan concentrations in the range 5x10(-7)-9x10(-7) M, with a detection limit of 1.25x10(-7) M (46.5 mu g L(-1)). The applicability of the method to spiked human urine samples was illustrated.eninfo:eu-repo/semantics/closedAccessDiatomiteCharacterizationModified Carbon Paste ElectrodeCyclic VoltammetrySquare-Wave Stripping VoltammetryNaratriptanUrineArticle138Q3Q370371120426734WOS:000280524800007