Bircan, H. Y.Inal, A.Ozcelik, U.Koc, B.Demirag, A.Moray, G.Kemik, O.2025-05-102025-05-1020141128-36022-s2.0-84940228433https://hdl.handle.net/20.500.14720/3916Kemik, Ozgur/0000-0002-4612-1428; Bircan, Huseyin Yuce/0000-0001-8196-9195; Moray, Gokhan/0000-0003-2498-7287; Demirag, Alp/0000-0001-7276-3240; Ozcelik, Umit/0000-0003-1073-2494OBJECTIVE: The aim of this study was to compare the LigaSure (R) Small Jaw Instrument (LSJI) with the conventional clamp-and-tie (CT) technique in thyroid surgery regarding complication rates (hematoma, hypocalcemia and recurrent nerve palsy), the duration of the operative procedure, and systemic and local inflammatory effects. PATIENTS AND METHODS: Fifty-four consecutive patients were randomized prospectively into two groups, a Conventional Clamp-Tie (CT) group and a LigaSure (R) Vessel Sealing System (LVSS) Group. Pre- and postoperative blood plasma samples were taken to measure the tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), calcium, parathormon, CRP levels and WBC, as well as the lymphocyte subset (CD3, CD4, CD8, CD16/56, CD19) counts. The drain fluid samples were collected after the removal of the drains to measure the levels of IL-6 and TNF-alpha. RESULTS: Both groups showed significant changes regarding peripheral blood CD3+, CD4+, and CD8+ T cell levels (p < 0.05). In the LVSS group, the level of CD16+56+ NK cells showed a significant decrease compared with the CT group (p < 0.05). The IL-6 and TNF-alpha levels in the drainage fluid were significantly higher in the LVSS group. CONCLUSIONS: We demonstrated that LSJI can decrease operative time. Although the systemic inflammatory effect of LSJI remains inconclusive, the local inflammatory effect was significant, which could cause early and late postoperative problems.eninfo:eu-repo/semantics/closedAccessLigasure (R)Vessel Sealing SystemsTotal ThyroidectomyTnf-AlphaIl-6Lymphocyte SubsetsArticle1814Q2Q21997200525027338WOS:000341977500006