Demir, NihatPeker, ErdalEce, IbrahimBalahoroglu, RagipTuncer, Oguz2025-05-102025-05-1020171476-70581476-495410.1080/14767058.2016.12388972-s2.0-85010634338https://doi.org/10.1080/14767058.2016.1238897https://hdl.handle.net/20.500.14720/12080Demir, Nihat/0000-0003-3287-7221Background: To compare rectal ibuprofen with oral ibuprofen for the closure of hemodynamically significant patent ductus arteriosus (hsPDA) in very low birth weight (VLBW) preterm infants.Study design and subjects: In a prospective, randomized study, 72 VLBW infants who had hsPDA received either rectal or oral ibuprofen. The plasma concentration of ibuprofen and renal functions were determined in both groups by the high-performance liquid chromatography (HPLC) method and cystatin-C (cys-C), respectively.Results: The hsPDA closure rate of the group that received rectal ibuprofen was similar to oral ibuprofen (86.1% versus 83.3%) after the first course of the treatment (p=0.745). A statistically significant difference was identified between the mean plasma cys-C levels before and after treatment in both the rectal and oral ibuprofen groups (p=0.004 and p<0.001, respectively). The mean plasma ibuprofen concentration was similar in both groups after the first dose (rectal 44.0612.4; oral, 48.28 +/- 22.8) and the third dose (rectal, 45.34 +/- 24.3; oral, 48.94 +/- 24.8) (p>0.05 for all values).Conclusions: Rectal ibuprofen is as effective as oral ibuprofen for hsPDA closure in VLBW infants. The rise in the cys-C level with rectal and oral treatment shows that patients with borderline renal function should be evaluated and followed closely.eninfo:eu-repo/semantics/closedAccessIbuprofenRectalOralPatent Ductus ArteriosusPretermArticle3017Q4Q22119212528052714WOS:000405211300019