Ozkol, HalilTuluce, YasinKoyuncu, IsmailBalahoroglu, Ragip2025-05-102025-05-1020111018-46191610-23042-s2.0-80955122890https://hdl.handle.net/20.500.14720/17181Koyuncu, Ismail/0000-0002-9469-4757The aim of this study was to determine protective effect of Centaurium erythraea L. on rats exposed to aspirin (ASA). The protective influence of the 50% aqueous-ethanolic Centaurium erythraea L. extract (AECE) (100 mg/kg body weight) was investigated in rats exposed to a single dose of 200 mg/kg body weight ASA administration. Twenty-one Sprague-Dawley albino rats were distributed into three groups equally (n=7) as follows: A (control), B (only ASA-treated) and C (ASA+AECE-treated) group. At the end of 4 h ASA administration to groups B and C, some serum biochemical constituents were assigned and compared between the groups. Results showed that levels of aspartate aminotransferase, alanine aminotransferase, creatinine and potassium increased in group B compared with the control group, but they were decreased significantly with AECE supplementation. While lipase activity decreased only in group B, level of uric acid decreased both in groups B and C compared with control group. In conclusion, the current trial has shown that treatment of AECE with ASA supplied relative protection against acute ASA toxicity through ameliorating some blood parameters.eninfo:eu-repo/semantics/closedAccessAspirin ToxicityBiochemical ConstituentsCentaurium Erythraea LRatsArticle2010AN/AN/A26992703WOS:000296690500007