Allahverdiyeva, ShabnamKeskin, ErtugrulPinar, Pinar TalayYunusoglu, OrucYardim, YavuzSenturk, Zuhre2025-05-102025-05-1020200925-96351879-006210.1016/j.diamond.2020.1079622-s2.0-85086013158https://doi.org/10.1016/j.diamond.2020.107962https://hdl.handle.net/20.500.14720/7104Senturk, Zuhre/0000-0002-0356-9345; Yunusoglu, Oruc/0000-0003-1075-9574; Yardim, Yavuz/0000-0002-9587-096XThis study is about the use of the boron-doped diamond electrode pretreated electrochemically (anodic and subsequent cathodic) in the voltammetric determination of hepatitis C antiviral drug ledipasvir. Cyclic voltammetric measurements revealed that the compound yielded two well-separated irreversible oxidation peaks (P-A1 and P-A2) in acidic medium. The dependence of intensities of currents and potentials on electrode pretreatment, pH and nature of the supporting electrolyte, and other variables was investigated by square-wave voltammetry. Determination of ledipasvir was performed in Britton-Robinson buffer (pH 2.0) on the basis of both P-A1 and P-A2, which offered linear concentration ranges 0.5-60.0 mu g mL(-1) (5.6 x 10(-7)-6.8 x 10(-5) mol L-1) and 5.0-60.0 mu g mL(-1) (5.6 x 10(-6)-6.8 x 10(-5) mol L-1), respectively, with detection limits of 0.12 mu g mL(-1) (1.4 x 10(-7) mol L-1) and 0.76 mu g mL(-1) (8.6 x 10(-7) mol L-1). The practical applicability of developed methodology was tested by the assay of a fixed-dose combination tablet with sofosbuvir.eninfo:eu-repo/semantics/closedAccessLedipasvirBoron-Doped Diamond ElectrodeSquare-Wave VoltammetryHarvoni (R) TabletsArticle108Q2Q2WOS:000569885400003