Menges, N.2025-05-102025-05-102021978012822446510.1016/B978-0-12-822446-5.00002-22-s2.0-85127674559https://doi.org/10.1016/B978-0-12-822446-5.00002-2https://hdl.handle.net/20.500.14720/2903Green chemistry is a fascinating research area due to its respect to environment and effectiveness for more purified organic compounds, which will be active pharmaceuticals. Twelve principles of green chemistry should be obeyed, and these principles can manage the researchers to enhance productivity and reduce hazardous effects on human health. Active pharmaceutical ingredients (API) should have adequate purity due to their use in human health. Any contamination coming from adopted protocols can influence the product. These disadvantages increase further purification protocols, which led to using more power, chemicals, and increase product cost. All these disadvantages can be dropped using green chemistry principles. © 2021 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessEnzymologyFlow ChemistryHeterocyclic ChemistryLow-Cost SynthesisSynthetic ProtocolsBook PartN/AN/A2140