Karaöz, EKanter, MBapçi, Z2025-05-102025-05-1020020901-33932-s2.0-0036984001https://hdl.handle.net/20.500.14720/4521Karaoz, Erdal/0000-0002-9992-833XThis experiment was carried out to demonstrate the effect of moclobemide on the brains of rats fed on a diet containing alcohol. Thirty male rats, 200250 g were used. Rats were fed with a diet (milk) containing ethyl alcohol (10%) in the alcohol-only treated group and were injected subcutaneously with moclobemide (30 mg/kg) in the alcohol+moclobemide treated group daily for 21 days. It is found that the serum ethanol level in the alcohol+moclobemide treated group was significantly higher than in alcohol-only treated group at the end of the experiment. Electron microscopic examination revealed more prominent neurotoxicity in the alcohol+moclobemide treated group than in alcohol-only treated group. We concluded that moclobemide decreases the elimination of ethanol. However, more studies are needed to demonstrate its mechanism.eninfo:eu-repo/semantics/closedAccessArticle294Q3Q4217225WOS:000180722200003