Elçi, G.G.Elçi, E.Kaya, C.Çim, N.Kolusarı, A.Erten, R.Bulut, G.2025-05-102025-05-1020171301-088310.5505/ejm.2017.263492-s2.0-85028558694https://doi.org/10.5505/ejm.2017.26349https://hdl.handle.net/20.500.14720/5065Different types of mesh materials are used to support pelvic structures in urogynecologic procedures. Our aim was to compare histopathological and mechanical effects of Prolene®, UltraPro®, Vypro II®, and Permacol® meshes used in pelvic organ prolapse. Thirty Sprague-Dawley rats were randomized into five groups. Group 1 served as a sham-operated control (n=6); Prolene® was used in group 2 (n=6), UltraPro® in group 3 (n=6), Vypro II® in group 4 (n=6), and Permacol® in group 5 (n=6). A 0.5 × 1 cm mesh was placed between the paravaginal tissue and bladder. After 12 weeks, the rats were reoperated and meshes were excised. Histopathological tissue reactions were compared. The muscle penetration rate was 67% in the Prolene® group, which was significantly higher than that in the other groups (p=0.026). Minimum preserved postoperative surface area was seen with Prolene® at 0.31 cm2 and maximum with UltraPro® at 0.45 cm2, which was statistically significant. UltraPro® had the most preserved postoperative surface area and less shrinkage than the other meshes. The mesh materials cause an inflammatory reaction in surrounding tissue. Prolene® mesh had superior muscle penetration and tensile strength compared to the other materials. © 2017, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.eninfo:eu-repo/semantics/openAccessPelvic Organ ProlapsePolypropyleneSurgical MeshTensile StrengthArticle222N/AQ44552