Altun, M. L.Citoglu, G. SaltanYilmaz, B. SeverOzbek, H.2025-05-102025-05-1020091388-02091744-511610.1080/138802009029183452-s2.0-77149120177https://doi.org/10.1080/13880200902918345https://hdl.handle.net/20.500.14720/9879Saltan, Hayriye Gulcin/0000-0001-6633-0713; Sever Yilmaz, Betul/0000-0003-2084-9514Water extract of Viburnum opulus L. (Caprifoliaceae) (VO) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VO causes dose related inhibition in acetic acid-induced abdominal stretching in mice. VO inhibited abdominal stretching at 100 and 200 mg/kg. VO showed antinociceptive activity, which was quantified by the tail-flick test at doses of 100 and 200 mg/kg. However, VO did not have an anti-inflammatory effect at these doses. The LD50 of VO was determined as 5.447 g/kg.eninfo:eu-repo/semantics/openAccessAnti-Inflammatory ActivityAntinociceptive ActivityMedian Lethal Dose (Ld50)Viburnum OpulusArticle477Q1Q2653658WOS:000282711400016