Taspinar, MehmetBozoglan, AlihanErtugrul, Abdullah SeckinElmas, Levent2025-05-102025-05-1020200327-95451667-574610.32604/biocell.2020.0114702-s2.0-85092309323https://doi.org/10.32604/biocell.2020.011470https://hdl.handle.net/20.500.14720/14014Bozoglan, Alihan/0000-0003-3420-5816This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins (HBD) HBD-2, HBD-3, and calprotectin. Atherosclerosis is the most frequently observed cardiovascular disease. Dental and periodontal infections are known to provide a considerable basis for atheroma plaque formation. The study group consists of a total number of 40 subjects, with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic periodontitis. Clinical periodontal and blood parameters and HBD-2, HBD-3, and calprotectin biomarkers in the gingival crevicular fluid were measured. In both groups, following clinical periodontal treatment, a statistically significant decrease in white blood cells (WBC), low-density lipoproteins (LDL), fibrinogen, creatinine, and platelets (PLT), a statistically significant increase in high-density lipoproteins (HDL) in blood samples, statistically meaningful decrease in HBD-2, HBD-3, and calprotectin in the gingival crevicular fluid were achieved. Blood values and HBD-2, HBD-3, calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group. A positive correlation was observed between decreases in HBD-2, HBD-3, calprotectin, and clinical periodontal indices. Regression in systemic inflammation was observed after clinical periodontal treatment. It is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.eninfo:eu-repo/semantics/openAccessAtherosclerosisPeriodontal DiseasesHbd-2Hbd-3CalprotectinArticle443Q4Q4337344WOS:000572676600008