Bodur, HaticeYurdakul, Fatma GulDuruoz, Mehmet TuncayCay, Hasan FatihUcar, UlkuKeskin, YasarSezer, Ilhan2025-05-102025-05-1020212148-50461309-028310.46497/ArchRheumatol.2021.82152-s2.0-85107826111https://doi.org/10.46497/ArchRheumatol.2021.8215https://hdl.handle.net/20.500.14720/10192Duruoz, Mehmet Tuncay/0000-0003-3584-2788; Demir, Ali Nail/0000-0001-5713-4120; Caglayan, Gokhan/0000-0003-4630-5849; Sen, Nesrin/0000-0003-0966-0075; Kaplan, Huseyin/0000-0002-3292-0907; Nas, Kemal/0000-0002-5845-0851; Alkan Melikoglu, Meltem/0000-0001-7519-9470; Yurdakul, Ozan Volkan/0000-0003-4567-8133; Ucar, Ulku/0000-0003-4838-1650; Karahan, Ali Yavuz/0000-0001-8142-913XObjectives: This study aims to evaluate the effectivity of Familial Mediterranean Fever Quality of Life (FMF-QoL) Scale for the measurement of QoL in patients with FMF and to perform correlations between related clinical variables in Turkish patients. Patients and methods: This multicenter prospective study performed between December 2017 and November 2018 included 974 FMF patients (334 males, 640 females; median age: 35; range, 26 to 45 years). Sociodemographic characteristics and clinical features were recorded. All participants were asked to complete the FMF-QoL Scale, Short Form-36 (SF-36), Hospital Anxiety and Depression Scale (HADS), Health Assessment Questionnaire (HAQ), and Functional Assessment of Chronic Illness Therapy (FACIT) Scale. Results: The median FMF-QoL Scale score was 26. Higher FMF-QoL Scale scores were shown to be related to female sex, illiteracy or primary education, monthly low-income (US$<300), smoking, late-onset FMF (>20 years), a higher number of attacks per month (>1/month), and severe disease. FMF-QoL Scale scores were correlated negatively with subscales of SF-36, and positively with HADS-anxiety and HADS-depression scores, HAQ and FACIT. Conclusion: Female sex, smoking, lower educational status, more severe disease, fatigue, and functional impairment were associated with poor QoL. FMF-QoL Scale was noted as a valid and simple patient-reported outcome instrument and correlated with the SF-36 scale.eninfo:eu-repo/semantics/openAccessAutoinflammatory DiseasesDepressionFatigueHereditaryLife QualityArticle362Q4Q315916634527919445721WOS:000657513700001