Arslan, B.Öner, A.F.Erseckin, A.Karaman, K.2025-11-302025-11-3020251301-08831309-388610.5505/ejm.2025.962372-s2.0-105020399257https://doi.org/10.5505/ejm.2025.96237https://hdl.handle.net/20.500.14720/29096In this study, it was aimed to retrospectively evaluate the epidemiological characteristics and long-term side effects related to hormon and bone metabolism in the follow-up of lymphoma patients between the ages of 0-18 years. 98 patients who were diagnosed with HL and NHL between 2007-2020 in the Van Yuzuncuyil University Pediatric Hematology Clinic were retrospectively scanned from the hospital database. The mean age of children was 96 months. It was determined that 74 (75.5%) children were boys and 24 (24.5%) were girls. No statistically significant difference was found in terms of age at diagnosis, and gender distribution of children diagnosed with HL and NHL (p=0.347, p=0.095, respectively). 25 OH vit-D deficiency was found in 21 (84%) children with a diagnosis of HL and 10 (71.4%) children with a diagnosis of NHL (p=0.187). Growth and developmental delay was found in 2 (2%) children with a diagnosis of HL. Early puberty was observed in 4 (4.1%) children, and delayed puberty was detected in 3 (5.5%) children. The median TSH, 25 OH vit-D levels and puberty findings were similar in NHL and HL group (p=0.241, p=0.399, p=0.505, respectively). Hypothyroidism was 5.1% before C hT-RT, it increased to 11.1% after ChT-RT. However, this difference was not statistically significant (p=0.241). We conclude that it is important to evaluate patients regularly in terms of endocrinological and metabolic side effects related to ChT and RT during the treatment process and long-term follow-up. © 2025, Yuzuncu Yil Universitesi Tip Fakultesi. All rights reserved.eninfo:eu-repo/semantics/openAccessBone MetabolismLymphomaPubertyThyroid FunctionArticle