Talmac, Ahmet CemilYayli, Nazli Zeynep AlpaslanCalisir, MetinErtugrul, Abdullah Seckin2025-05-102025-05-1020220021-12651863-436210.1007/s11845-021-02705-02-s2.0-85130725431https://doi.org/10.1007/s11845-021-02705-0https://hdl.handle.net/20.500.14720/8044Alpaslan, Nazli Zeynep/0000-0002-6311-385X; Calisir, Metin/0000-0001-6607-6532; Ertugrul, Abdullah Seckin/0000-0002-9973-3161; Talmac, Ahmet Cemil/0000-0002-7401-0936Background This study aims to determine the effects of Er,Cr:YSGG and diode laser treatments on IL-1 beta, IL-8, and TNF-alpha levels in patients with generalized aggressive periodontitis. Methods Twenty-six generalized aggressive periodontitis patients were enrolled in the study. We performed three treatment models: "scaling and root planning (SRP-only)," "SRP + Er,Cr:YSGG laser," and "SRP + diode laser." Each experimental quadrant was randomly allocated to the control group or the test group. The IL-1 beta, IL-8, and TNF-alpha levels were analyzed with an enzyme-linked immune-sorbent assay. Results When the baseline and post-treatment IL-1 beta, IL-8, and TNF-alpha levels were compared, the most significant difference was observed in the SRP +Er,Cr:YSGG group and the least difference was observed in the SRP-only group. Conclusions The use of Er,Cr:YSGG laser as an addition to the conventional mechanical periodontal treatment was found to be more successful than the diode laser + SRP use in aggressive periodontitis treatment.eninfo:eu-repo/semantics/closedAccessClinical Periodontal ParametersDiode LaserEr,Cr:Ysgg LaserGeneralized Aggressive PeriodontitisIl-1 BetaIl-8Tnf-AlphaArticle1913Q3Q11331133934263416WOS:000673435300001