Adali, ErtanYildizhan, RecepKurdoglu, MertihanBugdayci, GulerKolusari, AliSahin, H. Guler2025-05-102025-05-1020100015-02821556-565310.1016/j.fertnstert.2009.03.0372-s2.0-77953720441https://doi.org/10.1016/j.fertnstert.2009.03.037https://hdl.handle.net/20.500.14720/1848Kurdoglu, Mertihan/0000-0002-5344-9739; Bugdayci, Guler/0000-0002-4060-3354Objective: To evaluate carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor levels in young women with polycystic ovary syndrome (PCOS) and age-matched healthy controls, and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. Design: Clinical study. Setting: University hospital. Patient(s): Fifty young women with PCOS (overweight or obese [n = 24] and nonobese [n = 26]) and 25 age-matched healthy controls. Intervention(s): History and physical examination, peripheral venous blood sampling, carotid ultrasonography. Main Outcome Measure(s): Plasma thrombin-activatable fibrinolysis inhibitor, serum FSH, LH, DHEAS, total T, E-2, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglyceride, insulin resistance defined by the homeostasis model assessment insulin resistance index, and carotid intima-media thickness. Result(s): Plasma thrombin-activatable fibrinolysis inhibitor levels in the overweight or obese PCOS group were significantly higher than those in the nonobese PCOS and control groups. Carotid intima-media thickness did not significantly differ between the groups. Obesity and insulin resistance were associated positively with plasma thrombin-activatable fibrinolysis inhibitor levels, but there was no association between carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor. Conclusion(s): Young overweight or obese women with PCOS have increased plasma thrombin-activatable fibrinolysis inhibitor levels. Impaired fibrinolysis may be responsible for the increased risk of cardiovascular diseases in women with PCOS. (Fertil Steril (R) 2010;94:666-72. (C) 2010 by American Society for Reproductive Medicine.)eninfo:eu-repo/semantics/openAccessPolycystic Ovary SyndromeThrombin-Activatable Fibrinolysis InhibitorCarotid Intima-Media ThicknessCardiovascular DiseaseArticle942Q1Q166667219368913WOS:000279758800038