Allahverdiyeva, ShabnamCalisir, MeryemKeskin, ErtugrulYardim, YavuzSenturk, Zuhre2025-05-102025-05-1020200925-96351879-006210.1016/j.diamond.2020.1081462-s2.0-85095775293https://doi.org/10.1016/j.diamond.2020.108146https://hdl.handle.net/20.500.14720/6854Senturk, Zuhre/0000-0002-0356-9345; Yardim, Yavuz/0000-0002-9587-096X; Calisir, Meryem/0000-0002-9890-8943The present study describes the first electroanalytical investigation and the development of a novel voltammetric method for a sensitive, simple, fast, cheap and eco-friendly determination of eltrombopag (ELT). At a borondoped diamond electrode pretreated electrochemically (anodic and subsequent cathodic), the compound presented one or two oxidation steps at relatively low positive potentials within the pH range 6.0-12.0 by employing square-wave voltammetry. The sensitivity of the measurements was significantly enhanced with the positive effect of cetyltrimethylammonium bromide (CTAB) under the accumulation condition. In Britton-Robinson buffer pH 12.0 containing 2 x 10(-4) mol L-1 CTAB (after 30 s accumulation at open-circuit condition), there was a linear dependence of peak current at +0.19 V (vs. Ag/AgCl) and ELT concentration in the range of 0.1-12.5 mu g mL(-1) (2.3 x 10(-7)-2.8 x 10(-5) mol L-1) with a detection limit of 0.0125 mu g mL(-1) (5.7 x 10(-8) mol L-1). The developed approach could be used for ELT determination in commercial tablet formulations.eninfo:eu-repo/semantics/closedAccessEltrombopagBoron-Doped Diamond ElectrodeCetyltrimethylammonium BromideSquare-Wave Adsorptive Stripping VoltammetryPharmaceutical FormulationArticle110Q2Q2WOS:000599496800003