Yegin, Sevim CiftciDede, SemihaMis, LeylaYur, Fatmagul2025-05-102025-05-1020170163-49841559-072010.1007/s12011-016-0826-92-s2.0-84986243940https://doi.org/10.1007/s12011-016-0826-9https://hdl.handle.net/20.500.14720/11929Dede, Semiha/0000-0001-5744-6327This study was carried out to determine the effect of zinc on oxidative DNA damage in rats with experimental acute and chronic kidney deficiency. Six groups of five Wistar-Albino rats each were assigned as controls (C), acute kidney deficiency (AKD), zinc-supplemented (+Zn), acute kidney deficiency, zinc-supplemented (AKD + Zn), chronic kidney deficiency (CKD) and zinc-supplemented chronic kidney deficiency (CKD + Zn). The levels of 8-Oxo-2'-deoxyguanosine (8-OHdG) were determined, being the lowest in the CKD group (p < 0.05), higher in the C group than those of rats with CKD but lower than that of all the other groups (p < 0.05). There were no significant differences between the controls and the CKD + Zn group, or between the AKD and the +Zn groups. Among all groups, the highest 8-OHdG level was found in the AKD + Zn group (p < 0.05). DNA damage was greater in acute renal failure than in rats with chronic renal failure. The DNA damage in the zinc group was significantly higher than in the controls.eninfo:eu-repo/semantics/closedAccessDna DamageRenal ImpairZincArticle1762Q2Q133834127612456WOS:000396260000014