Investigation of Dna-Binding Activities of Zinc(Ii) and Cobalt(Ii) Phthalocyanine Compounds With 3,4,5-Trimethoxybenzyloxy Substituents

Arslantas, AliAgirtas, Mehmet Salih2025-05-102025-05-1020172365-654910.1002/slct.2017023622-s2.0-85041840052https://doi.org/10.1002/slct.201702362https://hdl.handle.net/20.500.14720/5850In this study, DNA-binding activities of previously synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) have been chosen for the study. The interaction of synthesized tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanine compounds with CT-DNA was investigated by using UV/Vis titrimetric method, fluorescence spectroscopy, cyclic voltammetry, thermal denaturation profile, gel electrophoresis and viscosty measurement in a Tris-HCI buffer at pH 7.0. The results indicated that tetrakis(3,4,5-trimethoxybenzyloxy)-substituted Zn(II) and Co(II) phthalocyanines (Pc4 and Pc5) can interact with CT-DNA via intercalation binding mode.eninfo:eu-repo/semantics/closedAccessCalf Thymus-DannDna BindingPhthalocyanine CompoundsUv-Vis SpectroscopyInvestigation of Dna-Binding Activities of Zinc(Ii) and Cobalt(Ii) Phthalocyanine Compounds With 3,4,5-Trimethoxybenzyloxy SubstituentsArticle235Q3Q31165911665WOS:000418400400044