Kiran, MusaKeskin, ErtugrulYardim, Yavuz2026-04-022026-04-0220260352-513910.2298/JSC250718094K2-s2.0-105033496015https://hdl.handle.net/123456789/30037https://doi.org/10.2298/JSC250718094KThis article reports on the development of an electroanalytical method for the quantitative determination of the selective estrogen receptor modulator raloxifene (RLX) using voltammetry at a pretreated boron-doped diamond in 0.04 mol L-1 Britton-Robinson (BR) supporting electrolyte at pH 2, generating two anodic oxidation peaks at approximately 0.79 V (PA1) and 1.46 V (PA2). Scan rate analysis revealed that both adsorption and diffusion mechanisms govern RLX transport to the electrode surface. Consequently, incorporating a preconcentration (deposition) step was hypothesized to enhance analytical sensitivity. Optimal deposition parameters, along with supporting electrolyte pH and square-wave voltammetry (SWV) modulation settings, were systematically optimized. Quantitative analysis w as based on the first anodic peak (PA1) in 0.04 mol L-1 BR buffer at pH 2, exhibiting a linear dynamic range from 0.025 to 5.0 mu g mL-1 (from 4.9x10-8 to 9.9x10-6 mol L-1) and a detection limit of 0.0073 mu g mL-1 (1.4x10-8 mol L-1). The method's applicability was validated by successfully quantifying RLX in pharmaceutical formulations.eninfo:eu-repo/semantics/openAccessBoron-Doped Diamond ElectrodeSensingPharmaceutical FormulationRaloxifeneSquare-Wave VoltammetryArticle