Kuzu, BurakGul, SergenTan, MeltemMenges, NurettinBalci, Metin2025-05-102025-05-1020212365-654910.1002/slct.2021000452-s2.0-85102117991https://doi.org/10.1002/slct.202100045https://hdl.handle.net/20.500.14720/7222Menges, Nurettin/0000-0002-5990-6275Ten different N-propargyl pyrrole derivatives having various substituents at the C-2 position were synthesized. These derivatives were converted into indolizine derivatives by the [2+2] cycloaddition reaction of pyrrole N-allene, forming in situ, by heating in PrOH in basic medium. The structures were characterized by NMR and X-ray crystallography. The N-propargylated derivatives smoothly underwent intermolecular cyclizations to produce indolizine derivatives in good yields. We proposed a radical mechanism for the dimerization. Reaction of an allene product with butylated hydroxytoluene (BHT), a radical scavenger, did not give any dimerization product. This result supports the radical reaction.eninfo:eu-repo/semantics/closedAccessAlleneIndolizineIntermolecular CyclizationRadical ReactionRadical ScavengerArticle69Q3Q323662372WOS:000625488000040