Yur, FBelge, FMert, NYörük, I2025-05-102025-05-1020030015-47252-s2.0-0042190422https://hdl.handle.net/20.500.14720/4614Mert, Nihat/0000-0001-7185-3316The aim of this study was to investigate changes in oxidative stress parameters of erythrocytes in twenty 3-4 year-old fluorotic sheep as compared to twenty controls. Malondialdehyde (MDA) levels (mean +/- SD) were significantly elevated in erthyrocytes of the fluorotic sheep (2.51 +/- 0.16 nmol/mL) in comparison to the control sheep (1.32 +/- 0.13 nmol/mL). Erythrocyte Na+-K+ adenosine-5'-triphosphatase (Na+-K+ ATPase) activity in the fluorotic sheep (0.003 +/- 0.0005 mumol Pi/mg protein/h) was significantly lower than in the controls (0.005 +/- 0.0005 mumol Pi/mg protein/h), as was the activity of glucose-6-phosphate dehydrogenase (G6PD) (510 +/- 23.30 mU/g Hb) compared to the controls (1418 +/- 85.40 mU/g Hb). The results are explained by fluoride-induced oxidative stress reflected in elevated erythrocyte MDA levels that cause decreased enzyme activity of Na+-K+ ATPase and G6PD by affecting membrane structure.eninfo:eu-repo/semantics/closedAccessFluorotic SheepGlucose-6-Phosphate DehydrogenaseMalondialdehydeNa+-K+ AtpaseSheep FluorosisArticle363Q4Q4152156WOS:000185380900003