Soner, Burak CemAcikgoz, EdaDuzagac, FahriyeParlayan, Cuneyd2025-05-102025-05-1020232458-89382564-728810.30621/jbachs.1140895https://doi.org/10.30621/jbachs.1140895https://hdl.handle.net/20.500.14720/10006Acikgoz, Eda/0000-0002-6772-3081; Soner, Burak/0000-0002-3712-3210; Duzagac, Fahriye/0000-0002-4130-2246Purpose: The low-density lipoprotein receptor gene (LDLR) family plays a fundamental role in many malignancies and may have a putative cancer-boosting function. In our study, we have attempted to comparatively investigate the differential gene expressions of LDLR family in a normal prostate epithelial cell line (RWPE-1), prostate cancer cell line (DU145 cell line), prostate cancer stem cells (DU145 CSCs), and non-CSCs (DU145 non-CSCs, bulk population). Material and Methods: Cancer stem cells in the DU-145 prostate cancer cell line were isolated by flow cytometry according to CD133 and CD44 cell surface properties. Whole transcriptome sequencing data was comprehensively analyzed for each group. The protein-protein interaction network was determined using the STRING protein database. Results: Our data showed that the expression levels of Low-density lipoprotein receptor-related proteins (LRPs) such as LRP1, LRP3, LRP8 and, LRP11 were increased in the DU145 CSCs relative to the normal prostate epithelial cell line. Conclusion: Overall, our data suggest that the LRP functions and/or the expression in prostate cancer may ultimately change the invasive phenotype of the CSCs.eninfo:eu-repo/semantics/openAccessLdlr Gen FamilyCancer Stem CellProstate CancerTranscriptional RegulatorsArticle71N/AN/A410417WOS:000933151700043