Sengul, CihanSen, AhmetBarutcu, SuleymanCakir, CayanSarikaya, Remzi2025-05-102025-05-1020210007-50271943-773010.1093/labmed/lmaa063https://doi.org/10.1093/labmed/lmaa063https://hdl.handle.net/20.500.14720/7320Objective: Hyperbilirubinemia is associated with protection against various oxidative stress-mediated diseases. We aimed to investigate the association between bilirubin and novel electrocardiography (ECG)-based ventricular repolarization parameters. Methods: We enrolled 201 healthy men with mild hyperbilirubinemia (group 1) and 219 healthy men with normal bilirubin levels (group 2). The Tpeak-Tend (Tp-e) interval (defined as the interval from the peak of the T wave to the end of the T wave), corrected (c) Tp-e interval, QT interval, cQT interval, and Tp-e interval/QT interval ratio were measured from leads V-5 and V-6 with 20 mm/mV amplitude and 50 mm/second rate. Results: The Tp-e interval, cTp-e interval, and Tp-e interval/QT interval ratio were significantly lower in group 1 compared with group 2. The cTp-e interval showed a significant negative correlation with total bilirubin, conjugated bilirubin, and unconjugated bilirubin. The cTp-e interval (odds ratio [OR], 0.900; P=.002) and Tp-e interval/QT interval ratio (OR, 0.922; P=.04) were significantly associated with mild hyperbilirubinemia. Conclusion: We showed the association of mild hyperbilirubinemia with decreased novel ECG-based ventricular repolarization parameters.eninfo:eu-repo/semantics/closedAccessBilirubinTp-E IntervalTp-E IntervalQt Interval RatioQt IntervalVentricular ArrhythmiaEcgArticle523N/AQ422623132885227WOS:000683385500007