Oksuz, MustafaYuce, SerdarKocak, Omer FarukCanbaz, YasinRagbetli, Murat CetinMercantepe, Tolga2025-05-102025-05-1020152000-656X2000-676410.3109/2000656X.2015.10474522-s2.0-84941196874https://doi.org/10.3109/2000656X.2015.1047452https://hdl.handle.net/20.500.14720/15560Mercantepe, Tolga/0000-0002-8506-1755Background: Medical ozone is a chemical agent that consists of three oxygen atoms and has antioxidant, angiogenic and vasodilator effects. This study evaluated the effects of medical ozone pre-treatment on flap survival. Materials and methods: Rats were divided into four groups of 10 rats each and a 9 x 3 cm McFarlane flap was used. Sham group: Neither surgical nor ozone pretreatment was used. Control group: No pretreatment was used after surgery. Preoperative ozone group: Preoperative 1 mg/kg ozone was given intraperitoneally for 7 days. No pretreatment was used after surgery. Postoperative ozone Group: Postoperative 1 mg/kg ozone was given intraperitoneally for 7 days. After postoperative 1 week, all groups were evaluated by surface area measurement, histopathology and electron microscopy. Results: With the experimental McFarlane flap model, the experimental groups had better surface area measurements, along with histopathological and electron microscopic results when compared with the control group. Conclusion: Medical ozone had positive effects on flap survival due to its antioxidant, angiogenic and vasodilator qualities.eninfo:eu-repo/semantics/closedAccessOzone Pre-TreatmentFlap NecrosisMcfarlane FlapArticle495Q4Q230030525998721WOS:000603365900001