Yilmaz, B. SeverCitoglu, G. SaltanAltun, M. L.Ozbek, H.2025-05-102025-05-1020071388-02091744-511610.1080/138802007012131872-s2.0-34247577183https://doi.org/10.1080/13880200701213187https://hdl.handle.net/20.500.14720/6718Sever Yilmaz, Betul/0000-0003-2084-9514Water extract of Viburnum lantana L. ( Caprifoliaceae) ( VL) leaf was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid-induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that VL causes dose-related inhibition in acetic acid-induced abdominal stretching in mice. VL inhibited abdominal stretching at 100 mg/kg, which is similar to that of aspirin, but this extract exhibited stronger antinociceptive activity than aspirin at a 200 mg/kg dose. VL showed powerful antinociceptive activity, which was quantified by a tail-flick test in 100 mg/kg dose. The anti-inflammatory activity of VL was not found to be significantly different at doses of 100 and 200 mg/kg. As a result, VL had shown slight anti-inflammatory activity compared with indomethacin. The LD50 of VL was determined as 2.169 g/kg.eninfo:eu-repo/semantics/closedAccessAnti-Inflammatory ActivityAntinociceptive ActivityMedian Lethal Dose (Ld50)Viburnum LantanaArticle453Q1Q2241245WOS:000246442700013