Cigerim, LeventKaplan, Volkan2025-05-102025-05-1020191698-694610.4317/medoral.225902-s2.0-85059267544https://doi.org/10.4317/medoral.22590https://hdl.handle.net/20.500.14720/15842Kaplan, Volkan/0000-0002-7605-1125Background: Postoperative pain is one of the most common complications. The aim of this study is to evaluate the analgesic efficacies of dexketoprofen trometamol and two different dosages of dexketoprofen trometamol + thiocolchicoside combination in the impacted third molar tooth operation. Material and Methods: This randomized, double-blind study included 75 patients who did not have any disease. Patients were assigned to 3 groups. Group 1 received 25 mg dexketoprofen trometamol + 4 mg thiocholchicoside, Group 2 received 25 mg dexketoprofen trometamol +8 mg thiocholchicoside, and Group 3 received 25 mg dexketoprofen trometamol. In each group, the analgesic medication was administered twice a day. starting 1 hour before the operation. The level of pain was assessed with VAS. Results: Patient age varied from 18 to 36 years. Of all patients. 59.2% (n=42) were female and 40.8% (n=29) were male. Drug side effects were observed in 28.17% (n=20) of the patients. Mean 24th hour VAS score was lower in dexketoprofen trometamol + 8 mg thiocolchicoside group compared to dexketoprofen trometamol group (p<0.05). There was no statistically significant difference between the three groups regarding drug side effects (p>0.05). Conclusions: Dexketoprofen trometamol + 8 mg thiocolchicoside combination has higher analgesic efficacy compared to dexketoprofen trometamol. More studies are needed to interpret the analgesic and anti-inflammatory effects of thiocholchicoside + dexketoprofen trometamol combination.eninfo:eu-repo/semantics/openAccessAnalgesicDexketoprofen TrometamolThiocolchicosideThird Molar SurgeryArticle241Q3Q1E114E12230573719WOS:000454632800016