Bilgili, Serap GunesOzkol, HalilKaradag, Ayse SerapOzkol, Hatice UceSeker, AyseCalka, OmerAslan, Mehmet2025-05-102025-05-1020131556-95271556-953510.3109/15569527.2013.7816162-s2.0-84883200389https://doi.org/10.3109/15569527.2013.781616https://hdl.handle.net/20.500.14720/16167Introduction: Previous studies have suggested that oxidative stress may play an important role in the pathogenesis of alopecia areata (AA) but these reports are limited and conflicting. Objectives: The aim of this study was to investigate serum paraoxonase-1 (PON1) activity and oxidative status in subjects with AA. Materials and methods: Thirty-nine subjects with AA and 39 healthy controls were enrolled. Serum PON1 activity, total antioxidant capacity (TAC), total oxidant status (TOS) and oxidative stress index (OSI) were determined. Results: Serum TAC levels and PON1 activity were significantly lower in the subjects with AA than controls (p=0.038, p=0.001, respectively), whereas TOS levels and OSI were significantly higher (both, p=0.001) in the subjects with AA. Conclusions: Our results suggest that reduced PON1 activity may be related to increased oxidant and decreased antioxidant levels. These data indicated that oxidant/antioxidant imbalance may play a role in the etiopathogenesis of AA.eninfo:eu-repo/semantics/closedAccessAlopecia AreataOxidative Stress IndexPon1 ActivityTotal Antioxidant CapacityTotal Oxidant StatusArticle324Q4Q329029323590718WOS:000323527300006