Karaca, M.Özbek, H.Him, A.Tütüncü, M.Akkan, H.A.Kaplanoǧlu, V.2025-05-102025-05-1020071304-388910.29333/ejgm/825252-s2.0-66149092033https://doi.org/10.29333/ejgm/82525https://hdl.handle.net/20.500.14720/6481Aim: Essential oil of Bergamot (BO) was investigated for anti-inflammatory activity using carrageenan-induced rat paw oedema test. Methods: For the anti-inflammatory activity measurement six different groups were established and BO was administered in three different doses: 0.025, 0.05 and 0.10 mL/kg. Indomethacin was used as a reference agent. Results: It was found that reduction in the inflammation was 95.70% with indomethacin, 27.56% with 0.025 mL/kg BO, 30.77% with 0.05 mL/kg BO and 63.39% with 0.10 mL/kg BO. Indomethacin showed the strongest anti-inflammatory activity among the drugs used. The strongest anti-inflammatory activity of BO was seen with 0.10 mL/kg dosage. Median effective dose (ED50) value of BO was found to be 0.079 mL/kg. Conclusion: The results showed that BO posseses promising anti-inflammatory effect.eninfo:eu-repo/semantics/openAccessAnti-Inflammatory ActivityBergamot OilCarrageenan-OedemaCitrus Aurantium Subsp. BergamiaArticle44N/AN/A176179