Kaba, MehmetPirincci, NecipYuksel, Mehmet BilgehanGecit, IlhanGunes, MustafaDemir, MuratDemir, Halit2025-05-102025-05-1020151677-55381677-611910.1590/S1677-5538.IBJU.2014.04602-s2.0-84983103132https://doi.org/10.1590/S1677-5538.IBJU.2014.0460https://hdl.handle.net/20.500.14720/15029Gunes, Mustafa/0000-0003-2044-9086Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9 +/- 11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4 +/- 10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20 degrees C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.eninfo:eu-repo/semantics/openAccessTesticular NeoplasmsTrace ElementsTumor Markers, BiologicalArticle416Q1Q21101110726742967WOS:000368286600011