Sahiner, MehtapAlpaslan, DuyguBitlisli, Behzat O.2025-05-102025-05-1020140170-08391436-244910.1007/s00289-014-1235-x2-s2.0-84919884514https://doi.org/10.1007/s00289-014-1235-xhttps://hdl.handle.net/20.500.14720/15770Sahiner, Mehtap/0000-0001-8666-7954; Alpaslan, Duygu/0000-0002-6007-3397; Bitlisli, Behzat Oral/0000-0003-1950-712XCollagen (coll)-containing hydrogel films were prepared by mixing degraded collagen with monomers such as acrylamide (AAm), and 2-hydroxy ethylmethacrylate (HEMA) before the polymerization/cross-linking of composites as p(coll-co-AAm), and p(coll-co-HEMA), respectively. These materials were used as drug-delivery devices for potential wound dressing materials by loading and releasing of model drugs such as gallic acid (GA) and naproxen (NP). A linear release profile was obtained up to 32-h release from GA-loaded p(coll-co-AAm) interpenetrating polymeric networks films, and 36-h linear release profile of NP for p(coll-co-HEMA). Furthermore, metal nanoparticles such as Ag and Cu prepared within these hydrogel films offered antimicrobial characteristic against known common bacteria such as Escherichia coli, Bacillus subtilis, and Staphylococcus aureus.eninfo:eu-repo/semantics/closedAccessHydrogel FilmsCollagen CompositesDrug-Delivery DevicesWound Dressing MaterialsSoft Polymeric FilmsArticle7111Q2Q230173033WOS:000343720300016