Surucu, ErdemPolack, Berna DegirmenciDemir, YusufDurmusoglu, MehmetEkmekci, SumeyyeSarioglu, AlienIkiz, Ahmet Omer2025-05-102025-05-1020150899-70711873-449910.1016/j.clinimag.2015.02.0042-s2.0-84938770637https://doi.org/10.1016/j.clinimag.2015.02.004https://hdl.handle.net/20.500.14720/7721Ada, Emel/0000-0002-0463-0945; Demir, Yusuf/0000-0001-6762-1977; Sarioglu, Sulen/0000-0003-4877-3064Aim: Our objective was to evaluate the diagnostic role of dual-phase fluor-18 fluorodeoxyglucose (F-18 FOG) positron emission tomography-computed tomography (PET-CT) and planar lymphoscintigraphy in patients with oral cavity cancer (OCC). We also investigated the combined impact of F-18 FOG PET-CT and sentinel lymph node biopsy (SLNB) in decision making for patients with OCC. Methods: Sixteen patients (4 female, 12 male; age range, 29-81 years) were included in this prospective study. F-18 FDG PET-CT [1 (early) and 2 h (delayed) after injection] and planar lymphoscintigraphy (2 h before the surgery) were performed for all the patients before surgery. The sensitivity, specificity, and negative and positive predictive values in F-18 FOG PET-CT for the early and the delayed scans and tumor/liver uptake (T/L) in the lymph nodes were calculated. Receiver operating characteristic curves were obtained for standardized uptake value (SUV)max and T/L. Results: Histopathological evaluations revealed that 5 patients had metastatic lymph nodes (pN+) whereas 11 patients had benign lymph nodes (pN). Out of 43 lymph nodes visualized as cN(+) in F-18 FDG PET-CT, 14 were pathologically positive for malignancy, whereas 29 were pathologically benign. There was no statistical difference between the N(+) and N(-) patients in terms of age, depth of primary tumor, and the number of mitoses. However, there was a significant difference between the N(+) and N(-) patients (P=.011) in terms of early and delayed F-18 FOG uptake of primary tumors. There was a statistically significant difference in the value of SUVmax between the early and the delayed scans for the malignant lymph nodes (P=.00). Conclusion: This study indicates that F-18 FOG PET-CT is a reliable method for the correct evaluation of primary tumor and N staging in OCCs. Delayed phase of F-18 FOG imaging may increase primary lesion detectability due to higher FDG uptake in primary tumors compared to the early phase of imaging. F-18 FOG PET-CF might demonstrate skip metastasis in lymph nodes which can be missed with SLNB. Although SUV values increased in the delayed phase of F-18 PET-CF imaging in detecting lymph node metastases, the specificity and positive predictive value did not increase. (C) 2015 Elsevier Inc. All rights reserved.eninfo:eu-repo/semantics/closedAccessF-18 Fdg Pet-CtDual PhaseOral Cavity CancersPlanar LymphoscintigraphyArticle395Q3Q278178625721710WOS:000360776900008