Taşdemir, V.2025-05-102025-05-1020222149-012010.18596/jotcsa.10644882-s2.0-85131163218https://doi.org/10.18596/jotcsa.1064488https://hdl.handle.net/20.500.14720/3031In this study, acetate derivatives were obtained from the reaction of acetophenones using diethyl carbonate. The acidic proton of CH2 moiety was abstracted using a suitable base and α-propargyl-β-ketoester (non-conjugated ynone) derivatives 3a-c were obtained from the reaction of the acetate derivatives with propargyl bromide. By removing the ester group of α propargyl-β-ketoester derivatives under suitable conditions, α-propargyl acetophenones (non-conjugated ynone) 4a-c were obtained. In this study, 6 different unconjugated ynone derivatives were synthesized as starting material with yield in a range of 60-95%. Cyclization reactions with propargyl amine in the presence of three different unconjugated ynone derivatives, metal catalysts were investigated. The synthesis of propargyl pyrroles 7a-c having substituents on C-2 and C-5 was completed. © 2022, Turkish Chemical Society. All rights reserved.eninfo:eu-repo/semantics/openAccessCyclizationPropargyl AminePyrroleUnconjugated YnoneArticle