Sekeroglu, M. RamazanAltun, Z. BusraAlgun, EkremDulger, HalukNoyan, TevfikBalaharoglu, RagipOzturk, Mustafa2025-05-102025-05-1020060741-238X10.1007/BF028501692-s2.0-33748770682https://doi.org/10.1007/BF02850169https://hdl.handle.net/20.500.14720/12292Altun, Zekiye/0000-0002-1558-4534; Noyan, Tevfik/0000-0002-7733-0177Hyperthyroidism is associated with increased bone turnover. Besides the hormones of calcium metabolism , locally produced factors are important in maintaining normal bone metabolism. Interleukin-6 (IL-6), in particular, has a major influence on bone turnover. In this study, serum IL-6 and tumor necrosis factor-alpha (TNF-alpha) levels, as well as bone turnover markers and relationships between them, were investigated in hyperthyroidism and hypothyroidism. A total of 20 female patients with hyperthyroidism, 15 with subclinical hyperthyroidism, 16 with hypothyroidism, and 15 with subclinical hypothyroidism constituted the patient groups. In all, 15 age-matched healthy female volunteers were recruited as controls. When compared with controls, serum TNF-a levels showed no significant difference in any of the patient groups (P >.05). In the groups with hyperthyroidism and subclinical hyperthyroidism, IL-6 levels were significantly higher compared with control group values (P <.05). Hyperthyroid patients showed higher levels of alkaline phosphatase (ALP) and osteocalcin, and a higher urinary deoxypyridinoline/creatinine ratio, compared with controls (P <.05). In subclinical hyperthyroidism, only ALP was found to be higher compared with control values. No significant correlations were made in any group between serum IL-6 or TNF-a level and bone turnover markers. Results suggest that serum IL-6 level and markers of bone turnover rate seem to be increased in hyperthyroidism. This finding may support the role of IL-6 in induction of bone turnover in hyperthyroid states.eninfo:eu-repo/semantics/closedAccessHyperthyroidismHypothyroidismIl-6Tnf-AlphaBone Turnover MarkerArticle233Q2Q147548016912030WOS:000240447500011