Allahverdiyeva, ShabnamKeskin, ErtugrulYoruk, IbrahimYardim, Yavuz2025-05-102025-05-1020232365-654910.1002/slct.2023001252-s2.0-85153409253https://doi.org/10.1002/slct.202300125https://hdl.handle.net/20.500.14720/1017For the first time, a boron-doped diamond electrode was utilized to quantitatively determine flavonoid fisetin (FST). Cyclic voltammetric studies have shown that the electrochemical oxidation of FST is irreversible and well-separated two peaks (P-A1 and P-A2) in 0.1 MHNO3 solution. The effects of electrode pretreatment, solution pH, nature of the supporting electrolyte, and instrumental variables on the peak current and potentials of the FST were investigated by square-wave voltammetry (SWV) and then optimum ones were determined. It was observed that the cathodically pre-treated BDD (CPT-BDD) electrode's performance was better than the other pre-treatment procedures for increasing the FST oxidation signal. Under optimized conditions and using the SWV technique, the response of the first anodic peak (P-A1) of the FST was proportional in a concentration range of 0.5-20.0 mu g mL(-1) (1.7x10(-6)-6.9x10(-5) mol L-1) with a detection limit of 0.08 mu gm L-1 (2.8 x 10(-7) mol L-1). Also, it was successfully demonstrated that the proposed method is applicable in commercial nutritional supplement formulations.eninfo:eu-repo/semantics/closedAccessBoron-Doped Diamond ElectrodeCommercial Dietary SupplementFisetinSquare-Wave VoltammetryArticle814Q3Q3WOS:000968370800001